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Researchers develop new system for effective cancer diagnosis and treatment

A research group consisting of scientists from NUST MISIS, the Technical University of Munich, Helmholtz Zentrum München, the University of Duisburg-Essen, and the University of Oldenburg has developed a system that allows doctors to both improve the accuracy of diagnosing malignant cells and to provide additional opportunities for cancer treatment. The magnetoferritin compound is the main element of this new system. The research article has been published in Advanced Functional Materials. The lack of accuracy ("contrast") in imaging is a common problem of non-invasive diagnosis. "Contrast agents", compounds that are introduced into the body before a diagnosis procedure to enhance the response and make affected cells more visible on a tomograph, can be used to solve this problem in magnetic resonance imaging (MRI). Paramagnetic gadolinium particles and superparamagnetic iron particles are among these agents. However, even in small quantities, these substances - alien to the human body - can potentially be dangerous. Related Stories Scientists identify pathways that reveal insights into mechanism of lung cancer etiology Gene therapy with telomerase does not increase cancer risk, study shows Discovery could lead to new targeted treatment for people with lung cancer "The international research team, including Dr. Ulf Wiedwald, a visiting Professor at the NUST MISIS Biomedical Nanomaterials Laboratory, has developed a unique injection diagnosis system based on magnetoferritin. The developed system will significantly improve the quality of MRIs and optical diagnosis", -- said Alevtina Chernikova, Rector of NUST MISIS. Magnetoferritin is a compound consisting of endogenous human protein (ferritin) and a magnetic nucleus. The development and testing of the compound was conducted following the existing protocol for the synthesis of magnetoferritin, but was improved for the effective capture of tumor cells. The high concentration of magnetoferritin in tumor tissue made it possible to obtain a hypoallergenic contrast agent that is perfectly compatible with the human body.
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